Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase.
نویسندگان
چکیده
منابع مشابه
Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate.
The GTP analog 5’-guanylyl-imidodiphosphate (Gpp(NH)p) caused marked stimulation of basal and catecholamine (isoproterenol)-sensitive adenylate cyclase from canine myocardium, frog erythrocytes and rat paraovarian fat. The combination of Gpp(NH)p (1OV M) and isoproterenol (10e4 M) produced activation of adenylate cyclase equal to (fat) or significantly greater than (heart, erythrocytes) that st...
متن کاملForskolin-activated adenylate cyclase. Inhibition by guanyl-5'-yl imidodiphosphate.
Forskolin activated adenylate cyclase of purified rat adipocyte membranes in the absence of exogenous guanine nucleotides. Guanyl-5'-yl imidodiphosphate (Gpp(NH)p) inhibited the forskolin-activated cyclase immediately upon addition of the nucleotide at concentrations too low to activate adenylate cyclase (10(-9) to 10(-7) M). Inhibition seen with a very high concentration of Gpp(NH)p (10(-4) M)...
متن کاملForskolin-activated Adenylate Cyclase
Forskolin activated adenylate cyclase of purified rat adipocyte membranes in the absence of exogenous guanine nucleotides. Guanyl-5”yl imidodiphosphate (Gpp(NH)p) inhibited the forskolin-activated cyclase immediately upon addition of the nucleotide at concentrations too low to activate adenylate cyclase (lo-’ to M). Inhibition seen with a very high concentration of Gpp(NH)p M) lasted for 3-4 m...
متن کاملE VALUATION OF ADENYLATE CYCLASE ACTIVITY IN MITRAL VALVE PROLAPSE
The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...
متن کاملA persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes.
Isoproterenol plus guanylyl imidodiphosphate (Gpp(NH)p) activate frog erythrocyte adenylate cyclase to a level much higher than the sum of the activities produced by the catecholamine and the synthetic nucleotide tested separately. Propranolol, the beta-receptor blocking agent, failed to inhibit activity when added after the enzyme system had been preincubated with both isoproterenol and Gpp(N...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1975
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)41318-5